Humeroradial Synostosis with Craniofacial Anomalies is an extremely rare skeletal condition characterized by humero-radial synostosis, rhizomelic limb shortening, and a distinctive craniofacial appearance, including high broad forehead and frontal hairline, sparse scalp hair, hypertelorism, epicanthus inversus, depressed nasal bridge, and exstropia, among others. So far, the condition has only been reported in two sisters in a Saudi family.