The TMEM38B gene encodes the trimeric intracellular cation channel type B (TRIC-B) protein that functions in the maintenance of intracellular calcium release.  These channels are localized predominantly to the sarco/endoplasmatic reticulum, where they function as counter ion channels that synchronize with ryanodine receptor-mediated Ca2+ release. 

Mutations in this gene are associated with Osteogenesis imperfecta, type XIV (OI14).