Shaheen et al. (2011) described two Saudi Arabian families with a phenotype that varied between isolated Osteogenesis Imperfecta and Bruck Syndrome.  Parents in both families were consanguineous.  The two affected sisters in family 1 had skeletal deformities, short stature and delayed development.  Mental development was normal in both.  Examination of heart, lung abdomen and central nervous system was unremarkable.  Pamidronate was given to the second sister at the age of 5-years, and she showed a significant improvement, as she was described as fracture-free for 4 years.  The affected children from the second family are cousins for patients in family 1.  The index case in family 2 is a 17-year- old boy.  He developed the first fracture during difficult labor.  He had frequent fractures (3 per year), never walked and developed scoliosis.  His brother developed fracture at age of 3-years and improved when pamidronate was administered.  Shaheen et al., (2011) identified two distinct mutations in the FKBP10 gene in the two families.  The authors affirmed that mutations in FKBP10 gene cause Bruck syndrome and isolated osteogenesis imperfecta.