Nonmetastatic Cells 3, Protein Expressed in

Alternative Names

  • NME3
  • DR-NM23
  • Nonmetastatic Protein 23, Homolog of
  • NM23H3
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OMIM Number

601817

Gene Map Locus
16p13.3

Description

The NME3 gene encodes a nucleoside diphosphate kinase protein.  As a kinase, this protein plays a major role in the synthesis of nucleoside triphosphates.  It is also involved in the purine and pyrimidine nucleotide metabolic process and in the regulation of cell apoptosis.  Additionally, the NME3 protein is speculated to be involved in hematopoiesis by the inhibition of granulocyte differentiation.

Molecular Genetics

The NME3 gene is located on the short arm of chromosome 16.  It spans a length of 1.4 kb and its coding sequence consists of five exons.  The gene contains putative binding sites for Sp1, AP2, MYB, ETS, GATA, and HOX1.  The protein encoded by this gene has a mass of 19 kDa and is made up of 169 amino acids.  The gene is found to be expressed highly in the nasal epithelium.  Studies of murine NME3 have found the gene to be preferentially expressed in the early stages of myeloid differentiation of highly purified CD34+ cells.  

Epidemiology in the Arab World

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Other Reports

Saudi Arabia

Shtir et al. (2016) aimed to identify candidate genes with SNPs that provide a protective effect against Diabetic Retinopathy (DR).  A total of 43 diabetics that had not developed DR 10-years after their diabetes diagnosis were recruited as cases, while 64 diabetics with DR were enrolled as controls.  Whole exome sequencing was carried out, and statistical analysis involved the combined multivariate and collapsing method at the gene level.  This helped identify the gene NME3 as a significant candidate (p=1.55x10-10).  The SNP rs11890 (g.1820992T>A) was more frequent in cases than controls and was hence suggested to confer protection against DR in diabetic patients [Risk Ratio= 4.61 (2.53, 8.40)].

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