Cyclin-Dependent Kinase Inhibitor 1C (CDKN1C) is a tumor suppressor; a protein involved in the regulation of cell division. Because it is a strong, tight inhibitor of several G1 cyclin/CDK complexes, this protein is a negative regulator of cell proliferation. One of the major functions of this protein is in controlling prenatal growth, by preventing the fetus from growing abnormally large.
Mutations in CDKN1C gene cause disorders like Beckwith Wiedemann Syndromem (BWS), a condition characterized by prenatal and postnatal overgrowth. In addition, defects in CDKN1C have also been shown to result in a condition known as Intrauterine growth restriction, Metaphyseal dysplasia, Adrenal hypoplasia congenita, and Genital anomalies (IMAGe). This condition is characterized by delayed prenatal and postnatal growth, and hormonal and genital abnormalities in males.