The NEMF gene encodes a protein that forms a component of the ribosome quality control complex. By recognizing an exposed, nascent chain-conjugated tRNA moiety, the NEMF protein is responsible for the selective recognition and ubiquitination of stalled 60s subunits by the ubiquitin ligase listerin. Further, as the name suggests, NEMF indirectly plays a role in nuclear export. Multiple isoforms of the NEMF protein exist due to alternative splicing. The gene is found to be expressed in the brain, heart, liver, lung, spleen and skeletal muscle.