Al-Salem et al.(2013) described a 15-month-old boy with Weaver Syndrome who presented with remarkably accelerated growth pattern; his growth parameters were: weight 18.2 kg, length 89 cm, and OFC 49 cm.  He had a flat occiput, downslanting palpebral fissures, round face, retrognathia, and hypertelorism with mild degree of exophthalmos.  His physical examination showed umbilical hernia and discrepancy in the size of the lower extremities with the left side being smaller.  The left side of his body also showed exaggerated reflexes, increased tone, and reduction of power.  A de novo c.2233G>A missense mutation in exon 20 of the EZH2 gene was identified in the affected patient, resulting in a Glu745Lys amino acid substitution.  This mutation was not found in 200 Saudi Exomes and the Exome Variants Server (ESV) and this de novo mutation is likely to be disease causing.