Coumarin Resistance

Alternative Names

Coumarin, Poor metabolism of
Warfarin Resistance
Coumarin Sensitivity
Warfarin Sensitivity

Associated Genes

Cytochrome P450, Subfamily IIC, Polypeptide 9; Vitamin K Epoxide Reductase Complex, Subunit 1

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WHO-ICD-10 version:2010

OMIM Number

122700

Mode of Inheritance

Autosomal dominant

Gene Map Locus

16p11.2

Description

Warfarin is a widely prescribed anticoagulant for the prevention of thromboembolic diseases for subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. The dose requirement is highly variable, both interindividually and interethnically. Variation in the VKORC1 gene is believed to be the most important individual predictor of warfarin dose, accounting for about 30% of the variance observed in dosing. [From OMIM]

Epidemiology in the Arab World

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Subject ID	Country	Sex	Family History	HPO Terms	Variant	Zygosity	Reference	Remarks
122700.G.1.1	Lebanon		No		NM_001311311.1:c.-1639G>A	Heterozygous	Djaffar-Jureidini et al. 2011	64 Healthy subjects ...
122700.G.1.2	Lebanon		No		NM_001311311.1:c.-1639G>A	Homozygous	Djaffar-Jureidini et al. 2011	55 Healthy subjects ...
122700.G.1.3	Lebanon		No		NM_000771.3:c.430C>T	Heterozygous	Djaffar-Jureidini et al. 2011	24 Healthy subjects ...
122700.G.1.4	Lebanon		No		NM_000771.4:c.1075A>C	Heterozygous	Djaffar-Jureidini et al. 2011	22 Healthy subjects ...
122700.G.1.5	Lebanon		No		NM_000771.3:c.430C>T	Homozygous	Djaffar-Jureidini et al. 2011	3 Healthy subjects w...
122700.G.1.6	Lebanon		No		NM_000771.3:c.430C>T	Heterozygous	Djaffar-Jureidini et al. 2011	4 Healthy subjects w...
122700.G.1.7	Lebanon		No		NM_000771.4:c.1075A>C	Homozygous	Djaffar-Jureidini et al. 2011	2 Healthy subjects w...
122700.G.1.8	Lebanon		No		NM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>T	Heterozygous	Djaffar-Jureidini et al. 2011	9 healthy subjects e...
122700.G.1.9	Lebanon		No		NM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>A	Heterozygous	Djaffar-Jureidini et al. 2011	8 healthy subjects c...
122700.G.1.10	Lebanon		No		NM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>T	Heterozygous, Homozygous	Djaffar-Jureidini et al. 2011	6 healthy subjects c...
122700.G.1.11	Lebanon		No		NM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>A	Heterozygous, Homozygous	Djaffar-Jureidini et al. 2011	13 healthy subjects ...
122700.G.1.12	Lebanon		No		NM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>T	Heterozygous, Homozygous	Djaffar-Jureidini et al. 2011	2 healthy subjects c...
122700.G.1.13	Lebanon		No		NM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>T	Heterozygous	Djaffar-Jureidini et al. 2011	2 healthy individual...
122700.G.1.14	Lebanon		No		NM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>A	Heterozygous, Homozygous	Djaffar-Jureidini et al. 2011	1 healthy subject ca...
122700.G.1.15	Lebanon		No		NM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>T	Homozygous	Djaffar-Jureidini et al. 2011	1 healthy individual...
122700.G.1.16	Lebanon		No		NM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>T	Heterozygous, Homozygous	Djaffar-Jureidini et al. 2011	1 healthy individual...
122700.G.1.17	Lebanon		No		NM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>A	Homozygous	Djaffar-Jureidini et al. 2011	1 healthy individual...
122700.G.2.1	Lebanon		No		NM_001311311.1:c.-1639G>A	Heterozygous	Esmerian et al. 2011	106 out of 231 total...
122700.G.2.2	Lebanon				NM_001311311.1:c.-1639G>A	Homozygous	Esmerian et al. 2011	68 out of 231 total ...
122700.G.2.3	Lebanon				NM_000771.3:c.430C>T	Heterozygous	Esmerian et al. 2011	52 out of 231 total ...
122700.G.2.4	Lebanon				NM_000771.4:c.1075A>C	Heterozygous	Esmerian et al. 2011	23 out of 231 total ...
122700.G.2.5	Lebanon				NM_000771.3:c.430C>T	Homozygous	Esmerian et al. 2011	5 out of 231 total s...
122700.G.2.6	Lebanon				NM_000771.4:c.1075A>C, NM_000771.3:c.430C>T	Heterozygous	Esmerian et al. 2011	9 out of 231 total s...
607473.G.5	Oman				NM_001311311.1:c.-1639G>A	Homozygous	Pathare et al. 2012	22 control Omani pop...
608547.G.2.1	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_001311311.1:c.-1639G>A	Heterozygous	Al-Mahayri et al. 2019	Study including 90 u...
608547.G.2.2	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_001311311.1:c.-1639G>A	Homozygous	Al-Mahayri et al. 2019	Study including 90 u...
608547.G.2.3	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_024006.6:c.106G>T	Heterozygous	Al-Mahayri et al. 2019	Study including 90 u...
608547.G.2.4	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_024006.6:c.106G>T	Homozygous	Al-Mahayri et al. 2019	Study including 90 u...
608547.G.2.8	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_024006.6:c.174-136C>T	Heterozygous	Al-Mahayri et al. 2019	Study including 90 u...
608547.G.2.9	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_024006.6:c.174-136C>T	Homozygous	Al-Mahayri et al. 2019	Study including 90 u...
608547.G.2.10	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_024006.6:c.283+124G>C	Heterozygous	Al-Mahayri et al. 2019	Study including 90 u...
608547.G.2.11	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_024006.6:c.283+124G>C	Homozygous	Al-Mahayri et al. 2019	Study including 90 u...
608547.G.2.12	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_024006.4:c.283+837T>C	Heterozygous	Al-Mahayri et al. 2019	Study including 90 u...
608547.G.2.13	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_024006.4:c.283+837=	Homozygous	Al-Mahayri et al. 2019	Study including 90 u...
608547.G.2.14	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_024006.6:c.*134G>A	Heterozygous	Al-Mahayri et al. 2019	Study including 90 u...
608547.G.2.15	United Arab Emirates	Unknown		Atrial fibrillation; Deep vein thrombosi... Atrial fibrillation; Deep vein thrombosis; Cardiomyopathy; Hypercoagulability; Stroke; Pulmonary embolism	NM_024006.6:c.*134=	Homozygous	Al-Mahayri et al. 2019	Study including 90 u...