Coumarin Resistance

Alternative Names

  • Coumarin, Poor metabolism of
  • Warfarin Resistance
  • Coumarin Sensitivity
  • Warfarin Sensitivity
Back to search Result
WHO-ICD-10 version:2010
OMIM Number

122700

Mode of Inheritance

Autosomal dominant

Gene Map Locus

16p11.2

Description

Warfarin is a widely prescribed anticoagulant for the prevention of thromboembolic diseases for subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. The dose requirement is highly variable, both interindividually and interethnically. Variation in the VKORC1 gene is believed to be the most important individual predictor of warfarin dose, accounting for about 30% of the variance observed in dosing. [From OMIM]

Epidemiology in the Arab World

View Map
Subject IDCountrySexFamily HistoryParental ConsanguinityHPO TermsVariantZygosityMode of InheritanceReferenceRemarks
122700.G.1.1LebanonNoNM_001311311.1:c.-1639G>AHeterozygousDjaffar-Jureidini et al. 2011 64 Healthy subjects ...
122700.G.1.2LebanonNoNM_001311311.1:c.-1639G>AHomozygousDjaffar-Jureidini et al. 2011 55 Healthy subjects ...
122700.G.1.3LebanonNoNM_000771.3:c.430C>THeterozygousDjaffar-Jureidini et al. 2011 24 Healthy subjects ...
122700.G.1.4LebanonNoNM_000771.4:c.1075A>CHeterozygousDjaffar-Jureidini et al. 2011 22 Healthy subjects ...
122700.G.1.5LebanonNoNM_000771.3:c.430C>THomozygousDjaffar-Jureidini et al. 2011 3 Healthy subjects w...
122700.G.1.6LebanonNoNM_000771.3:c.430C>THeterozygousDjaffar-Jureidini et al. 2011 4 Healthy subjects w...
122700.G.1.7LebanonNoNM_000771.4:c.1075A>CHomozygousDjaffar-Jureidini et al. 2011 2 Healthy subjects w...
122700.G.1.8LebanonNoNM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>THeterozygousDjaffar-Jureidini et al. 2011 9 healthy subjects e...
122700.G.1.9LebanonNoNM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>AHeterozygousDjaffar-Jureidini et al. 2011 8 healthy subjects c...
122700.G.1.10LebanonNoNM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>THeterozygous, HomozygousDjaffar-Jureidini et al. 2011 6 healthy subjects c...
122700.G.1.11LebanonNoNM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>AHeterozygous, HomozygousDjaffar-Jureidini et al. 2011 13 healthy subjects ...
122700.G.1.12LebanonNoNM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>THeterozygous, HomozygousDjaffar-Jureidini et al. 2011 2 healthy subjects c...
122700.G.1.13LebanonNoNM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>THeterozygousDjaffar-Jureidini et al. 2011 2 healthy individual...
122700.G.1.14LebanonNoNM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>AHeterozygous, HomozygousDjaffar-Jureidini et al. 2011 1 healthy subject ca...
122700.G.1.15LebanonNoNM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>THomozygousDjaffar-Jureidini et al. 2011 1 healthy individual...
122700.G.1.16LebanonNoNM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>A, NM_000771.3:c.430C>THeterozygous, HomozygousDjaffar-Jureidini et al. 2011 1 healthy individual...
122700.G.1.17LebanonNoNM_000771.4:c.1075A>C, NM_001311311.1:c.-1639G>AHomozygousDjaffar-Jureidini et al. 2011 1 healthy individual...
122700.G.2.1LebanonNoNM_001311311.1:c.-1639G>AHeterozygousEsmerian et al. 2011 106 out of 231 total...
122700.G.2.2LebanonNM_001311311.1:c.-1639G>AHomozygousEsmerian et al. 2011 68 out of 231 total ...
122700.G.2.3LebanonNM_000771.3:c.430C>THeterozygousEsmerian et al. 2011 52 out of 231 total ...
122700.G.2.4LebanonNM_000771.4:c.1075A>CHeterozygousEsmerian et al. 2011 23 out of 231 total ...
122700.G.2.5LebanonNM_000771.3:c.430C>THomozygousEsmerian et al. 2011 5 out of 231 total s...
122700.G.2.6LebanonNM_000771.4:c.1075A>C, NM_000771.3:c.430C>THeterozygousEsmerian et al. 2011 9 out of 231 total s...
607473.G.5OmanNM_001311311.1:c.-1639G>AHomozygousPathare et al. 2012 22 control Omani pop...
608547.G.2.1United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_001311311.1:c.-1639G>AHeterozygousAl-Mahayri et al. 2019 Study including 90 u...
608547.G.2.2United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_001311311.1:c.-1639G>AHomozygousAl-Mahayri et al. 2019 Study including 90 u...
608547.G.2.3United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_024006.6:c.106G>THeterozygousAl-Mahayri et al. 2019 Study including 90 u...
608547.G.2.4United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_024006.6:c.106G>THomozygousAl-Mahayri et al. 2019 Study including 90 u...
608547.G.2.8United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_024006.6:c.174-136C>THeterozygousAl-Mahayri et al. 2019 Study including 90 u...
608547.G.2.9United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_024006.6:c.174-136C>THomozygousAl-Mahayri et al. 2019 Study including 90 u...
608547.G.2.10United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_024006.6:c.283+124G>CHeterozygousAl-Mahayri et al. 2019 Study including 90 u...
608547.G.2.11United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_024006.6:c.283+124G>CHomozygousAl-Mahayri et al. 2019 Study including 90 u...
608547.G.2.12United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_024006.4:c.283+837T>CHeterozygousAl-Mahayri et al. 2019 Study including 90 u...
608547.G.2.13United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_024006.4:c.283+837=HomozygousAl-Mahayri et al. 2019 Study including 90 u...
608547.G.2.14United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_024006.6:c.*134G>AHeterozygousAl-Mahayri et al. 2019 Study including 90 u...
608547.G.2.15United Arab EmiratesUnknown Atrial fibrillation; Deep vein thrombosi...NM_024006.6:c.*134=HomozygousAl-Mahayri et al. 2019 Study including 90 u...
© CAGS 2024. All rights reserved.