Insulin-Like Growth Factor 2 mRNA-Binding Protein 2

Alternative Names

IGF2BP2
IGF2 MRNA-Binding Protein 2
IMP2

Length

181,926 bases

No. of Exons

No. of isoforms

Protein Name

Insulin-like growth factor 2 mRNA-binding protein 2

Molecular Mass

66121 Da

Amino Acid Count

599

Genomic Location

chr3:185,643,131-185,825,056

Gene Map Locus

3q27.2

Description

IGF2BP2 gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. [From RefSeq]

Epidemiology in the Arab World

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Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_006548.6:c.239+11861T>G	Lebanon; Tunisia	NC_000003.12:g.185811292A>C		Association	Type 2 Diabetes Mellitus	NG_011602.1:g.18748T>G; NM_006548.6:c.239+11861T>G	1470579
NM_006548.6:c.239+29254C>A	Lebanon	chr3:185793899	Risk factor	Association	Type 2 Diabetes Mellitus	NG_011602.1:g.36141C>A; NM_006548.6:c.239+29254C>A	4402960	2435

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=IGF2BP2

Contributors

Asha Deepthi: 20.05.2020

Edit History

Asha Deepthi: 20.05.2020

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