DIS3-Like 3-Prime-5-Prime Exoribonuclease 2

Alternative Names

DIS3L2
DIS3 Mitotic Control, S. Cerevisiae, Homolog-Like 2

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Length

383,106 bases

No. of Exons

No. of isoforms

Protein Name

DIS3-like exonuclease 2

Molecular Mass

99279 Da

Amino Acid Count

885

Genomic Location

chr2:231,961,245-232,344,350

Gene Map Locus

2q37.1

Description

The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [From RefSeq]

Epidemiology in the Arab World

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Lebanon

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_152383.5:c.1651_1652insGGG	Lebanon	chr2:232263432-232263433		Uncertain Significance	Breast Cancer	NG_032572.1:g.306850_306851insGGG; NM_152383.5:c.1651_1652insGGG; NP_689596.4:p.Leu551delinsTrpVal

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=DIS3L2 https://www.ncbi.nlm.nih.gov/gene/129563

Contributors

Pratibha Nair: 13.09.2020

Edit History

Pratibha Nair: 13.09.2020