Angiotensin I

Alternative Names

  • AGT
  • SERPINA8
  • IgA Nephropathy, Progression to Renal Failure in, Susceptibility to
  • Angiotensin I
  • Angiotensin II

Associated Diseases

Hypertension, Essential
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OMIM Number

106150

Gene Map Locus
1q42.2

Description

Angiotensin is formed from a precursor, angiotensinogen, which is produced by the liver and found in the alpha-globulin fraction of plasma. The lowering of blood pressure is a stimulus to secretion of renin by the kidney into the blood. Renin cleaves from angiotensinogen a terminal decapeptide, angiotensin I. This is further altered by the enzymatic removal of a dipeptide to form angiotensin II.

Molecular Genetics

The human angiotensinogen molecule has a molecular weight of about 50,000 Da. The angiotensin I decapeptide is located in its N-terminal part. The human angiotensinogen gene is assigned to 1q4 in the same region as the renin gene and contains 5 exons.

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_001384479.1:c.593C>TUnited Arab EmiratesNC_000001.11:g.230710231G>ABenignBenignNG_008836.1:g.9360C>T; NM_001384479.1:c.593C>T; NP_000020.1:p.Thr207Met4762296083
NM_001384479.1:c.776T>CLebanon; United Arab E...NC_000001.11:g.230710048A>GBenignAssociation, Benign, ProtectiveHypertension, Essential; Major Depressive DisorderNG_008836.1:g.9543T>C; NM_001384479.1:c.776T>C; NP_000020.1:p.Met268Thr69918068
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