ATP-Binding Cassette, Subfamily C, Member 6

Alternative Names

  • ABCC6
  • Anthracycline Resistance-Associated Protein
  • ARA
  • Multidrug Resistance-Associated Protein 6
  • MRP6
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OMIM Number

603234

NCBI Gene ID

368

Uniprot ID

O95255

Length

74,053 bases

No. of Exons

34

No. of isoforms

3

Protein Name

Multidrug resistance-associated protein 6

Molecular Mass

164906 Da

Amino Acid Count

1503

Genomic Location

chr16:16,149,564-16,223,616

Gene Map Locus
16p13.11

Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_001171.5:c.3803G>ALebanonNC_000016.10:g.16157742C>TBenign, Likely BenignDrug ResponseBreast CancerNG_007558.2:g.70730G>A; NM_001171.5:c.3803G>A; NP_001162.4:p.Arg1268Gln22384726570
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