Interferon-Alpha, -Beta, and -Omega Receptor 2

Alternative Names

IFNAR2

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Length

35,727 bases

No. of Exons

No. of isoforms

Protein Name

Interferon alpha/beta receptor 2

Molecular Mass

57759 Da

Amino Acid Count

515

Genomic Location

chr21:33,229,937-33,265,663

Gene Map Locus

21q22.11

Description

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. [From RefSeq]

Epidemiology in the Arab World

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Lebanon

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_207585.2:c.611C>G	Lebanon	NC_000021.9:g.33252732C>G	Benign, Uncertain Significance	Uncertain Significance	Familial Mediterranean Fever	NG_016003.1:g.27807C>G; NM_207585.2:c.611C>G; NP_997468.1:p.Thr204Arg	147496374	775442

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=ifnar2

Contributors

Sayeeda Hana: 10.02.2021

Edit History

Sayeeda Hana: 10.02.2021