Tumor Necrosis Factor Receptor Superfamily, Member 8

Alternative Names

TNFRSF8
Lymphoid Activation Antigen CD30
CD30

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Length

80,911 bases

No. of Exons

No. of isoforms

Protein Name

Tumor necrosis factor receptor superfamily member 8

Molecular Mass

63747 Da

Amino Acid Count

595

Genomic Location

chr1:12,063,302-12,144,212

Gene Map Locus

1p36.22

Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. [From RefSeq]

Epidemiology in the Arab World

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Lebanon

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_001243.5:c.1511G>A	Lebanon	NC_000001.11:g.12138404G>A		Uncertain Significance		NG_029573.2:g.80028G>A; NM_001243.5:c.1511G>A; NP_001234.3:p.Arg504Gln	2230627

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=tnfrsf8

Contributors

Sayeeda Hana: 10.02.2021

Edit History

Sayeeda Hana: 10.02.2021