Interleukin 12A

Alternative Names

IL12A
IL12, P35 Subunit
Cytotoxic Lymphocyte Maturation Factor
CLMF
Natural Killer Cell Stimulatory Factor, 35-kD Subunit
NKSF1
IL35, P35 Subunit

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Length

7,185 bases

No. of Exons

No. of isoforms

Protein Name

Interleukin-12 subunit alpha

Molecular Mass

24874 Da

Amino Acid Count

219

Genomic Location

chr3:159,988,834-159,996,018

Gene Map Locus

3q25.33

Description

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. [From RefSeq]

Epidemiology in the Arab World

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Lebanon

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_000882.4:c.631G>A	Lebanon	NC_000003.12:g.159995428G>A	Benign, Uncertain Significance	Uncertain Significance		NG_033022.1:g.11593G>A; NM_000882.4:c.631G>A; NP_000873.2:p.Val211Met	35990253	708885
NM_002187.2:c.*159A>C	Lebanon	NC_000005.10:g.159315942T>G	Benign	Benign		NG_009618.1:g.19532A>C; NM_002187.2:c.*159A>C; NP_002178.2:p.?	3212227	352569

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=il12a

Contributors

Sami Bizzari: 29.03.2021
Sayeeda Hana: 11.02.2021

Edit History

Sami Bizzari: 29.03.2021
Sayeeda Hana: 11.02.2021