Interleukin 17 Receptor B

Alternative Names

IL17RB
Interleukin 17B Receptor
IL17BR
Interleukin 17 Receptor Homolog 1
IL17RH1

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Length

20,839 bases

No. of Exons

No. of isoforms

Protein Name

Interleukin-17 receptor B

Molecular Mass

55885 Da

Amino Acid Count

502

Genomic Location

chr3:53,846,549-53,867,387

Gene Map Locus

3p21.1

Description

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [From RefSeq]

Epidemiology in the Arab World

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Lebanon

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_018725.4:c.529G>A	Lebanon	NC_000003.12:g.53855341G>A		Uncertain Significance	Familial Mediterranean Fever	NM_018725.4:c.529G>A; NP_061195.2:p.Gly177Arg	2232337

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=il17rb

Contributors

Sayeeda Hana: 11.02.2021

Edit History

Sayeeda Hana: 11.02.2021