Interleukin 20

Alternative Names

  • IL20
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OMIM Number

605619

NCBI Gene ID

50604

Uniprot ID

Q9NYY1

Length

5,659 bases

No. of Exons

8

No. of isoforms

2

Protein Name

Interleukin-20

Molecular Mass

20072 Da

Amino Acid Count

176

Genomic Location

chr1:206,863,564-206,869,222

Gene Map Locus
1q32.1

Description

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_018724.3:c.225+1G>TLebanonNC_000001.11:g.206866365G>TUncertain SignificanceFamilial Mediterranean FeverNM_018724.3:c.225+1G>T138566326
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