Solute Carrier Family 22 (Extraneuronal Monoamine Transporter), Member 3

Alternative Names

  • SLC22A3
  • Extraneuronal Monoamine Transporter
  • EMT
  • Organic Cation Transporter 3
  • OCT3

Associated Diseases

Type 2 Diabetes Mellitus
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OMIM Number

604842

NCBI Gene ID

6581

Uniprot ID

O75751

Length

106,605 bases

No. of Exons

15

No. of isoforms

1

Protein Name

Solute carrier family 22 member 3

Molecular Mass

61280 Da

Amino Acid Count

556

Genomic Location

chr6:160,348,377-160,454,981

Gene Map Locus
6q25.3

Description

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [From RefSeq]

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_021977.3:c.1289-261T>CLebanonNC_000006.12:g.160442500T>CBenignNM_021977.3:c.1289-261T>C2048327
NM_021977.3:c.429+432A>GUnited Arab EmiratesNC_000006.12:g.160349280A>GAssociationType 2 Diabetes MellitusNM_021977.3:c.429+432A>G; NP_068812.1:p.?474513
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