Obesity due to mutation in the MC4R gene is the most common cause of monogenic obesity. Patients have early-onset severe obesity and hyperphagia. [From OMIM]
Endocrine, nutritional and metabolic diseases
Obesity and other hyperalimentation
Autosomal dominant Autosomal recessive
18q21.32
Obesity due to mutation in the MC4R gene is the most common cause of monogenic obesity. Patients have early-onset severe obesity and hyperphagia. [From OMIM]
| Subject ID | Country | Sex | Family History | Parental Consanguinity | HPO Terms | Variant | Zygosity | Mode of Inheritance | Reference | Remarks |
|---|---|---|---|---|---|---|---|---|---|---|
| 618406.1 | United Arab Emirates | Unknown |  | NM_005912.3:c.485C>T | Homozygous | Autosomal, Recessive | Ben-Rebeh et al. 2012 |