Intellectual Developmental Disorder with Neuropsychiatric Features

Alternative Names

  • IDDNPF
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WHO-ICD-10 version:2010

Mental and behavioural disorders

Mental retardation

OMIM Number

617532

Mode of Inheritance

Autosomal Recessive

Gene Map Locus

1p36.23

Description

Intellectual developmental disorder with neuropsychiatric features is an autosomal recessive disorder characterized by moderate intellectual disability, relatively mild seizures, and neuropsychiatric abnormalities, such as anxiety, obsessive-compulsive behavior, and autistic features. Mild facial dysmorphic features may also be present. [From OMIM]

Epidemiology in the Arab World

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Subject IDCountrySexFamily HistoryParental ConsanguinityHPO TermsVariantZygosityMode of InheritanceReferenceRemarks
617532.1.1PalestineFemaleYesYes Intellectual disability; Delayed speech ...NM_001379614.1:c.629C>THomozygousAutosomal, RecessiveSrour et al. 2017 Patient 'A.II-2' in ...
617532.1.2PalestineFemaleYesYes Intellectual disability; Seizure; Autist...NM_001379614.1:c.629C>THomozygousAutosomal, RecessiveSrour et al. 2017 Patient 'A.II-3' in ...
617532.2.1United Arab EmiratesMaleYesYes Global developmental delay; Delayed spee...NM_001379614.1:c.526C>THomozygousAutosomal, RecessiveSrour et al. 2017 Patient 'B.II-3' in ...
617532.2.2United Arab EmiratesMaleYesYes Failure to thrive; Global developmental ...NM_001379614.1:c.526C>THomozygousAutosomal, RecessiveSrour et al. 2017 Patient 'B.II-4' in ...
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