Ubiquitin Specific Peptidase 37

Alternative Names

  • USP37
  • KIAA1594
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NCBI Gene ID

57695

Uniprot ID

Q86T82

Length

118,143 bases

No. of Exons

27

No. of isoforms

2

Protein Name

Ubiquitin carboxyl-terminal hydrolase 37

Molecular Mass

110,170 Da

Amino Acid Count

979

Genomic Location

chr2:218,450,251-218,568,393

Gene Map Locus
2q35

Description

USP37 gene encodes ubiquitin carboxyl-terminal hydrolase 37 protein, which is involved in cell division and regulation of DNA replication. This protien affects G1/S transition of mitotic cell cycle by protein deubiquitination and it is also involved in ubiquitin-dependent protein catabolism.

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_020935.2:c.1670+635=United Arab EmiratesNC_000002.12:g.218485029=AssociationType 2 Diabetes Mellitus; ObesityNM_020935.2:c.1670+635=; NP_065986.2:p.?492400
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