MN1 Protooncogene, Transcriptional Regulator

Alternative Names

  • MN1
  • MN1 Gene
  • Meningioma Chromosome Region 1
  • MGCR1
  • MN1/Tel Fusion Gene

Associated Diseases

CEBALID Syndrome
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OMIM Number

156100

NCBI Gene ID

4330

Uniprot ID

Q10571

Length

53,480 bases

No. of Exons

2

No. of isoforms

1

Protein Name

Transcriptional activator MN1

Molecular Mass

136001 Da

Amino Acid Count

1320

Genomic Location

chr22:27,748,276-27,801,755

Gene Map Locus
22q12.1

Description

Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [From RefSeq]

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinical SignificanceCondition(s)HGVS ExpressionsdbSNPClinvar
NM_002430.3:c.1579C>TUnited Arab EmiratesNC_000022.11:g.27798965G>ALikely PathogenicCEBALID SyndromeNG_023258.1:g.7534C>T; NM_002430.3:c.1579C>T; NP_002421.3:p.Gln527Ter
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