MN1 Protooncogene, Transcriptional Regulator

Alternative Names

MN1
MN1 Gene
Meningioma Chromosome Region 1
MGCR1
MN1/Tel Fusion Gene

Length

53,480 bases

No. of Exons

No. of isoforms

Protein Name

Transcriptional activator MN1

Molecular Mass

136001 Da

Amino Acid Count

1320

Genomic Location

chr22:27,748,276-27,801,755

Gene Map Locus

22q12.1

Description

Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [From RefSeq]

Epidemiology in the Arab World

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United Arab Emirates

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_002430.3:c.1579C>T	United Arab Emirates	NC_000022.11:g.27798965G>A		Likely Pathogenic	CEBALID Syndrome	NG_023258.1:g.7534C>T; NM_002430.3:c.1579C>T; NP_002421.3:p.Gln527Ter

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External Links

https://medlineplus.gov/genetics/gene/mn1/ https://www.genecards.org/cgi-bin/carddisp.pl?gene=mn1

Contributors

Pratibha Nair: 14.09.2021

Edit History

Pratibha Nair: 14.09.2021

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