Glucokinase Regulatory Protein

Alternative Names

  • GCKR
  • GKRP
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OMIM Number

600842

NCBI Gene ID

2646

Uniprot ID

Q14397

Length

26,851 bases

No. of Exons

20

No. of isoforms

2

Protein Name

Glucokinase regulatory protein

Molecular Mass

68685 Da

Amino Acid Count

625

Genomic Location

chr2:27,496,838-27,523,688

Gene Map Locus
2p23.3

Description

This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinical SignificanceCondition(s)HGVS ExpressionsdbSNPClinvar
NM_001486.3:c.1423-418T=United Arab EmiratesNC_000002.12:g.27518370=NG_028024.1:g.26532=; NM_001486.3:c.1423-418T=780094
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