Inhibitor Of Nuclear Factor Kappa-B Kinase, Subunit Epsilon

Alternative Names

Ikbke
Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells, Kinase Of, Epsilon
I-Kappa-B Kinase-Epsilon
Ikke
Ikk-Epsilon
Inducible I-Kappa-B Kinase
Ikki
Kiaa0151

Length

26,648 bases

No. of Exons

No. of isoforms

Protein Name

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Molecular Mass

80462 Da

Amino Acid Count

716

Genomic Location

chr1:206,470,242-206,496,889

Gene Map Locus

1q32.1

Description

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

Epidemiology in the Arab World

View Map

United Arab Emirates

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_014002.4:c.541-5G>A	United Arab Emirates	NC_000001.11:g.206476673G>A	Uncertain Significance	Uncertain Significance	Systemic Lupus Erythematosus	NM_014002.4:c.541-5G>A; NP_054721.1:p.?	187136164	987751

Download Table

External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=ikbke

Contributors

Sami Bizzari: 27.01.2022

Edit History

Sami Bizzari: 03.02.2022
Sami Bizzari: 27.01.2022

Back to search Result