ATP-Binding Cassette, Subfamily C, Member 4

Alternative Names

  • ABCC4
  • Multidrug Resistance-Associated Protein 4
  • MRP4
  • Multispecific Organic Anion Transporter B
  • MOATB
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OMIM Number

605250

NCBI Gene ID

10257

Uniprot ID

O15439

Length

281,617 bases

No. of Exons

36

No. of isoforms

4

Protein Name

ATP-binding cassette sub-family C member 4

Molecular Mass

149527 Da

Amino Acid Count

1325

Genomic Location

chr13:95,019,834-95,301,450

Gene Map Locus
13q32.1

Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [From RefSeq]

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_005845.5:c.3348G>CUnited Arab EmiratesNC_000013.11:g.95062722C>GNG_050651.2:g.243725G>C; NM_005845.5:c.3348G>C; NP_005836.2:p.Lys1116Asn1751034
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