Interleukin 10 Receptor, Beta

Alternative Names

  • IL10RB
  • IL10R2
  • Cytokine Receptor Family II, Member 4
  • CRFB4
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OMIM Number

123889

NCBI Gene ID

3588

Uniprot ID

Q08334

Length

30,855 bases

No. of Exons

7

No. of isoforms

1

Protein Name

Interleukin-10 receptor subunit beta

Molecular Mass

36995 Da

Amino Acid Count

325

Genomic Location

chr21:33,266,366-33,297,220

Gene Map Locus
21q22.11

Description

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_000628.4:c.804+190_804+191insGAAGTCTGAGTUnited Arab EmiratesNC_000021.9:g.33288451_33288452insGAAGTCTGAGTNG_012089.1:g.27085_27086insGAAGTCTGAGT; NM_000628.4:c.804+190_804+191insGAAGTCTGAGT; NP_000619.3:p.?8178524
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