Thiosulfate Sulfurtransferase

Alternative Names

  • TST
  • Rhodanese
  • RDS
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OMIM Number

180370

NCBI Gene ID

7263

Uniprot ID

Q16762

Length

9,325 bases

No. of Exons

4

No. of isoforms

1

Protein Name

Thiosulfate sulfurtransferase

Molecular Mass

33429 Da

Amino Acid Count

297

Genomic Location

chr22:37,010,858-37,020,182

Gene Map Locus
22q12.3

Description

This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_003312.6:c.596-2524_596-2520dupUnited Arab EmiratesNC_000022.11:g.37013849_37013853dupNG_027994.1:g.10602_10606dup; NM_003312.6:c.596-2524_596-2520dup; NP_003303.2:p.?16363
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