DOT1-Like

Alternative Names

DOT1L
DOT1, S. cerevisiae, Homolog of
DOT1
Histone H3 Methyltransferase DOT1-Like
Kiaa1814

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Length

68,646 bases

No. of Exons

No. of isoforms

Protein Name

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Molecular Mass

164856 Da

Amino Acid Count

1537

Genomic Location

chr19:2,163,932-2,232,577

Gene Map Locus

19p13.3

Description

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [From RefSeq]

Epidemiology in the Arab World

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United Arab Emirates

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_032482.2:c.*2430A>G	United Arab Emirates	NC_000019.10:g.2232222A>G				NG_029793.1:g.73074A>G; NM_032482.2:c.*2430A>G; NP_115871.1:p.?	740406
NM_032482.3:c.82-4126A>G	United Arab Emirates	NC_000019.10:g.2176587A>G				NG_029793.1:g.17439A>G; NM_032482.3:c.82-4126A>G; NP_115871.1:p.?	12459350

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=dot1l

Contributors

Pratibha Nair: 04.04.2022

Edit History

Pratibha Nair: 04.04.2022