Protein Phosphatase 2, Regulatory Subunit B (B56), Alpha

Alternative Names

  • PPP2R5A
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OMIM Number

601643

NCBI Gene ID

5525

Uniprot ID

Q15172

Length

76,444 bases

No. of Exons

14

No. of isoforms

2

Protein Name

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

Molecular Mass

56194 Da

Amino Acid Count

486

Genomic Location

chr1:212,285,409-212,361,852

Gene Map Locus
1q32.3

Description

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [From RefSeq]

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_006243.4:c.182-2044C>TUnited Arab EmiratesNC_000001.11:g.212327091C>TNM_006243.4:c.182-2044C>T; NP_006234.1:p.?4951588
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