Tensin 1

Alternative Names

  • TNS1
  • Tensin
  • TNS
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OMIM Number

600076

NCBI Gene ID

7145

Uniprot ID

Q9HBL0

Length

234,192 bases

No. of Exons

48

No. of isoforms

2

Protein Name

Tensin-1

Molecular Mass

185701 Da

Amino Acid Count

1735

Genomic Location

chr2:217,799,790-218,033,981

Gene Map Locus
2q35

Description

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_001308023.2:c.3526=United Arab EmiratesNC_000002.12:g.217818431=NM_001308023.2:c.3526=; NP_001294952.1:p.Trp1176=2571445
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