KBTBD2 is the substrate recognition subunit of a CUL3-based E3 ubiquitin ligase. KBTBD2 targets p85-alpha, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for ubiquitination and proteasome-mediated degradation. [From OMIM]
KBTBD2 is the substrate recognition subunit of a CUL3-based E3 ubiquitin ligase. KBTBD2 targets p85-alpha, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for ubiquitination and proteasome-mediated degradation. [From OMIM]