Microphthalmia designates a heterogeneous group of ocular malformations with a more or less evident reduction in the size of the eyeball. Additional features include high hypermetropia and a short axial length. The size of the anterior chamber and the cornea may also be reduced, whereas the lens is normal or thicker than usual for age. Isolated microphthalmia-8 (MCOP8) is caused by homozygous mutation in the ALDH1A3 gene on chromosome 15q26. [From OMIM]