Wnt Ligand Secretion Mediator

Alternative Names

  • WLS
  • Wntless, Drosophila, Homolog of
  • G Protein-Coupled Receptor 177
  • GPR177
  • Evenness Interrupted, Drosophila, Homolog of
  • EVI

Associated Diseases

Zaki Syndrome
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OMIM Number

611514

NCBI Gene ID

79971

Uniprot ID

Q5T9L3

Length

134,088 bases

No. of Exons

13

No. of isoforms

3

Protein Name

Protein wntless homolog

Molecular Mass

62253 Da

Amino Acid Count

541

Genomic Location

chr1:68,098,459-68,232,546

Gene Map Locus
1p31.3

Description

Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_024911.7:c.1175A>GUnited Arab EmiratesNC_000001.11:g.68145972T>CPathogenicPathogenicZaki SyndromeNM_024911.7:c.1175A>G; NP_079187.3:p.Tyr392Cys1098567
NM_024911.7:c.1433A>GEgyptNC_000001.11:g.68137863T>CPathogenicPathogenicZaki SyndromeNM_024911.7:c.1433A>G; NP_079187.3:p.Tyr478Cys9853470961098568
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