Synaptonemal Complex Protein 2

Alternative Names

  • SYCP2
  • SCP2

Associated Diseases

Spermatogenic Failure 1
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OMIM Number

604105

NCBI Gene ID

10388

Uniprot ID

Q9BX26

Length

70,067 bases

No. of Exons

45

No. of isoforms

1

Protein Name

Synaptonemal complex protein 2

Molecular Mass

175639 Da

Amino Acid Count

1530

Genomic Location

chr20:59,863,571-59,933,637

Gene Map Locus
20q13.33

Description

The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [From RefSeq]

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_014258.4:c.866A>CSaudi ArabiaNC_000020.11:g.59912383T>GLikely PathogenicSpermatogenic Failure 1NG_046980.1:g.26299A>C; NM_014258.4:c.866A>C; NP_055073.2:p.Asp289Ala
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