Dead-Box Helicase 25

Alternative Names

  • DDX25
  • Dead-Box Polypeptide 25
  • Gonadotropin-Regulated Testicular RNA Helicase
  • GRTH

Associated Diseases

Spermatogenic Failure 1
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OMIM Number

607663

NCBI Gene ID

29118

Uniprot ID

Q9UHL0

Length

25,516 bases

No. of Exons

13

No. of isoforms

2

Protein Name

ATP-dependent RNA helicase DDX25

Molecular Mass

54692 Da

Amino Acid Count

483

Genomic Location

chr11:125,903,328-125,928,843

Gene Map Locus
11q24.2

Description

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [From RefSeq]

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_013264.5:c.275C>TSaudi ArabiaNC_000011.10:g.125906173C>TLikely PathogenicSpermatogenic Failure 1NG_033067.1:g.2049G>A; NM_013264.5:c.275C>T; NP_037396.3:p.Pro92Leu988388555
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