ROS Protooncogene 1, Receptor Tyrosine Kinase

Alternative Names

ROS1
V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1
Oncogene ROS
ROS
MCF3
ROS1/FIG Fusion Gene

Length

138,590 bases

No. of Exons

No. of isoforms

Protein Name

Proto-oncogene tyrosine-protein kinase ROS

Molecular Mass

263915 Da

Amino Acid Count

2347

Genomic Location

chr6:117,287,353-117,425,942

Gene Map Locus

6q22.1

Description

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [From RefSeq]

Epidemiology in the Arab World

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Saudi Arabia

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_001378902.1:c.4982C>T	Saudi Arabia	NC_000006.12:g.117341214G>A		Likely Pathogenic	Spermatogenic Failure 1	NM_001378902.1:c.4982C>T; NP_001365831.1:p.Pro1661Leu	866472077

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=ROS1 https://www.lung.org/lung-health-diseases/lung-disease-lookup/lung-cancer/symptoms-diagnosis/biomarker-testing/ros1 https://www.ncbi.nlm.nih.gov/gene/6098

Contributors

Pratibha Nair: 20.03.2023

Edit History

Pratibha Nair: 20.03.2023

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