Adhesion G Protein-Coupled Receptor A3

Alternative Names

  • ADGRA3
  • G Protein-Coupled Receptor 125
  • GPR125
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OMIM Number

612303

NCBI Gene ID

166647

Uniprot ID

Q8IWK6

Length

128,691 bases

No. of Exons

23

No. of isoforms

4

Protein Name

Adhesion G protein-coupled receptor A3

Molecular Mass

146151 Da

Amino Acid Count

1321

Genomic Location

chr4:22,387,376-22,516,066

Gene Map Locus
4p15.2

Description

This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [From RefSeq]

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_145290.4:c.2504C>GSaudi ArabiaNC_000004.12:g.22392668G>CUncertain SignificanceLikely PathogenicRetinitis PigmentosaNG_032963.1:g.128387C>G; NM_145290.4:c.2504C>G; NP_660333.2:p.Ser835Cys562486549834484
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