Centrosomal Protein, 76-kD

Alternative Names

  • CEP76
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OMIM Number

620791

NCBI Gene ID

5818

Uniprot ID

Q15223

Length

40,822 bases

No. of Exons

10

No. of isoforms

3

Protein Name

Nectin-1

Molecular Mass

57158 Da

Amino Acid Count

517

Genomic Location

chr18:12,661,956-12,702,777

Gene Map Locus
18p11.21

Description

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_024899.4:c.302T>CSyriaNC_000018.10:g.12699197A>GLikely PathogenicNM_024899.4:c.302T>C; NP_079175.2:p.Ile101Thr763465512
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