Eukaryotic Translation Elongation Factor 1, Delta

Alternative Names

  • EEF1D
  • Elongation Factor 1, Delta
  • EF1D
  • EEF1B-Delta
  • Guanine Nucleotide Exchange Protein
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OMIM Number

130592

NCBI Gene ID

1936

Uniprot ID

P29692

Length

17,688 bases

No. of Exons

12

No. of isoforms

4

Protein Name

Elongation factor 1-delta

Molecular Mass

31122 Da

Amino Acid Count

281

Genomic Location

chr8:143,579,728-143,597,415

Gene Map Locus
8q24.3

Description

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_001130053.5:c.69delSyriaNC_000008.11:g.143590014delLikely PathogenicNM_001130053.5:c.69del; NP_001123525.3:p.Glu24SerfsTer26
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