DENN Domain-Containing Protein 4B

Alternative Names

  • DENND4B
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OMIM Number

619843

NCBI Gene ID

9909

Uniprot ID

O75064

Length

17,394 bases

No. of Exons

30

Protein Name

DENN domain-containing protein 4B

Molecular Mass

163847 Da

Amino Acid Count

1496

Genomic Location

chr1:153,929,501-153,946,894

Gene Map Locus
1q21.3

Description

This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_014856.3:c.2702_2703insGCAGCSaudi ArabiaNC_000001.11:g.153934830_153934831insGCTGCLikely PathogenicNM_014856.3:c.2702_2703insGCAGC; NP_055671.2:p.Gln903HisfsTer48375088543
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