Folate Receptor, Alpha

Alternative Names

FOLR1
Folate Receptor 1, Adult
Folate-Binding Protein, Adult
FBP
Folate Receptor
FOLR
Ovarian Cancer-Associated Antigen
MOV18

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Length

6,615 bases

No. of Exons

No. of isoforms

Protein Name

Folate receptor alpha

Molecular Mass

29819 Da

Amino Acid Count

257

Genomic Location

chr11:72,189,709-72,196,323

Gene Map Locus

11q13.4

Description

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. [From RefSeq]

Epidemiology in the Arab World

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Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_016729.3:c.1A>G	Qatar	NC_000011.10:g.72192174A>G	Likely Pathogenic	Pathogenic		NG_015863.1:g.7617A>G; NM_016729.3:c.1A>G; NP_057941.1:p.Met1?	1057524829	393190

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External Links

https://medlineplus.gov/genetics/gene/folr1/ https://www.genecards.org/cgi-bin/carddisp.pl?gene=FOLR1

Contributors

Sayeeda Hana: 13.12.2024

Edit History

Sayeeda Hana: 13.12.2024