Midline 2

Alternative Names

MID2
Midin 2

Length

105,903 bases

No. of Exons

No. of isoforms

Protein Name

Probable E3 ubiquitin-protein ligase MID2

Molecular Mass

83210 Da

Amino Acid Count

735

Genomic Location

chrX:107,825,735-107,931,637

Gene Map Locus

Xq22.3

Description

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [From RefSeq]

Epidemiology in the Arab World

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Tunisia

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_012216.4:c.166C>T	Tunisia	NC_000023.11:g.107840831C>T		Uncertain Significance	Intellectual Developmental Disorder, X-Linked 101	NG_011907.2:g.19978C>T; NM_012216.4:c.166C>T; NP_036348.2:p.Arg56Cys	1458358006

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=MID2

Contributors

Asha Deepthi: 10.03.2025

Edit History

Asha Deepthi: 10.03.2025

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