Bromodomain- and PHD Finger-Containing Protein

Alternative Names

BRPF1
Bromodomain-Containing Protein, 140-Kd
BR140
Peregrin

Length

16,281 bases

No. of Exons

No. of isoforms

Protein Name

Peregrin

Molecular Mass

137499 Da

Amino Acid Count

1214

Genomic Location

chr3:9,731,735-9,748,015

Gene Map Locus

3p25.3

Description

This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [From RefSeq]

Epidemiology in the Arab World

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Saudi Arabia

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_001003694.2:c.2600C>T	Saudi Arabia	NC_000003.12:g.9743866C>T		Uncertain Significance	Intellectual Developmental Disorder with Dysmorphic Facies and Ptosis	NG_052955.1:g.17138C>T; NM_001003694.2:c.2600C>T; NP_001003694.1:p.Ala867Val	2471502793

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=BRPF1

Contributors

Asha Deepthi: 24.04.2025

Edit History

Asha Deepthi: 24.04.2025

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