BLK Protooncogene, SRC Family Tyrosine Kinase

Alternative Names

  • BLK
  • Tyrosine Kinase, B-Lymphocyte Specific

Associated Diseases

Type 2 Diabetes Mellitus
Back to search Result
OMIM Number

191305

NCBI Gene ID

640

Uniprot ID

P51451

Length

70,213 bases

No. of Exons

16

Protein Name

Tyrosine-protein kinase Blk

Molecular Mass

57706 Da

Amino Acid Count

505

Genomic Location

chr8:11,494,387-11,564,599

Gene Map Locus
8p23.1

Description

This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_001715.3:c.530A>GQatarNC_000008.11:g.11554800A>GUncertain SignificanceType 2 Diabetes MellitusNG_023543.2:g.65789A>G; NM_001715.3:c.530A>G; NP_001706.2:p.Tyr177Cys775313404
© CAGS 2025. All rights reserved.