NK6 Homeobox 1

Alternative Names

NKX6-1
NK6, Drosophila, Homolog of, 1
NKX6.1
NK Homeobox, Family 6, Member A
Homeobox 6A, NK
NKX6A

Length

7,308 bases

No. of Exons

Protein Name

Homeobox protein Nkx-6.1

Molecular Mass

37849 Da

Amino Acid Count

367

Genomic Location

chr4:84,491,985-84,499,292

Gene Map Locus

4q21.23

Description

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes. [From OMIM]

Epidemiology in the Arab World

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Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_006168.3:c.155C>T	Qatar	NC_000004.12:g.84498074G>A		Uncertain Significance	Type 2 Diabetes Mellitus	NM_006168.3:c.155C>T; NP_006159.2:p.Ser52Phe	1720864004
NM_006168.3:c.84G>C	Qatar	NC_000004.12:g.84498145C>G		Uncertain Significance	Type 2 Diabetes Mellitus	NM_006168.3:c.84G>C; NP_006159.2:p.Met28Ile	369821275

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=NKX6-1

Contributors

Asha Deepthi: 09.05.2025

Edit History

Asha Deepthi: 22.05.2025
Asha Deepthi: 09.05.2025

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