Sadat-Ali and Al-Turki analyzed three SNP variants in three genes: ALOX15 (rs7220870), LRP5 (C 25752205 10), and TNFRSF11B (C 11869235 10) that influence Bone Mineral Density (BMD) among postmenopausal Saudi women between January 2009 and June 2010.  The majority of the women 69% were homozygous CC for the ALOX15 C>A SNP with low BMD in the hip region and lower history fracture than the other alleles, while 4% were homozygous for A allele with higher BMD.  Over 96% of the women carried CC and CT for the LRP5 C>T SNP.  The women with the homozygous TT showed high BMD at the hip and spine and there were no fragility fracture.  In the TNFRSF11B SNP; the majority of the women carried AA and AG alleles, and only 3% were homozygous for G allele.  BMD of the hip and spine was significantly higher in the GG allele, and higher prevalence of fractures.  While in the A allele women, there was risk of low BMD and higher risk of osteoporosis without fractures.  This study revealed that reported SNPs in the ALOX 15, LPR5, and TNFRSF11B, have an influence in BMD, osteoporosis, and fragility fractures among Saudi females.