Ovarian cysts are fluid filled sacs on the surface of the ovary. Fetal and neonatal ovarian cysts have previously been considered uncommon. With the development of prenatal and postnatal ultrasonography, however, the detection of cysts has increased. Ovarian cysts usually become clinically apparent only during childhood adolescence. Unilateral cysts are more common than bilateral, and unilocular cysts, are more common than multilocular cysts. An ovarian cyst should be suspected when a female has a cystic intra-abdominal mass which is separate from the organs of the urinary and gastrointestinal tract. Any cystic ovarian enlargement is almost always benign, but complications occur such as torsion of the ovarian cyst leading to signs of an acute abdomen and small bowel obstruction. This may be the first clinical sign of the cyst if it had not yet been detected by prenatal or postnatal ultrasonography. However, larger cysts carry a greater risk of torsion with subsequent loss of the ovary, and hence a surgical intervention is indicated.
Familial ovarian cancer shows an autosomal dominant inheritance pattern. Structural and numerical chromosomal abnormalities are usually observed in the ovarian tumor tissues. Multiple loci in chromosome 2, 6, 9, 11, and 17 are known to be associated with ovarian cancer. Studies have also observed a small percent of early-onset ovarian cancer patients with germline mutations in MLH1, MSH2, and tumor suppressor genes BRCA1 and BRCA2.