608320.G.2.3

Country

United Arab Emirates

HPO Terms

Myocardial infarction; Abnormal coronary artery morphology; Type II diabetes mellitus; Abnormal circulating lipid concentration; Hypertension

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Sex

Unknown

Subject Variants

Variant Name	Allele Count	Allele Frequency	Associated Disease
NM_018256.3:c.1195-225A>G	NA	0.078	Coronary Artery Disease, Autosomal Dominant, 1
NM_000237.2:c.776-172G>A	NA		Coronary Artery Disease, Autosomal Dominant, 1
NR_135674.1:n.45+8018T>C	NA	0.428	Coronary Artery Disease, Autosomal Dominant, 1
NM_000235.3:c.229+2506G>A	NA	0.470	Coronary Artery Disease, Autosomal Dominant, 1
NM_000301.3:c.1256+9T>C	NA		Coronary Artery Disease, Autosomal Dominant, 1
NG_006669.2:g.1491=	NA	0.111	Coronary Artery Disease, Autosomal Dominant, 1
NC_000011.10:g.103789839=	NA	0.426	Coronary Artery Disease, Autosomal Dominant, 1
NM_000235.3:c.230-954=	NA	0.444	Coronary Artery Disease, Autosomal Dominant, 1
NC_000021.9:g.34223520A>G	NA	0.145	Coronary Artery Disease, Autosomal Dominant, 1
NM_001321868.1:c.*1090T>C	NA	0.158	Coronary Artery Disease, Autosomal Dominant, 1
NM_003761.4:c.*143T>C	NA		Coronary Artery Disease, Autosomal Dominant, 1
NC_000001.11:g.55030366T>C	NA	0.147	Coronary Artery Disease, Autosomal Dominant, 1
NC_000004.12:g.147472512C>T	NA	0.238	Coronary Artery Disease, Autosomal Dominant, 1
NM_173598.4:c.385+27792A>C	NA		Coronary Artery Disease, Autosomal Dominant, 1
NC_000002.12:g.21065449=	NA	0.205	Coronary Artery Disease, Autosomal Dominant, 1
NR_033870.2:n.464-26926=	NA		Coronary Artery Disease, Autosomal Dominant, 1
NM_001846.2:c.181-27458T>C	NA	0.165	Coronary Artery Disease, Autosomal Dominant, 1
NM_001085049.2:c.*1011C>T	NA		Coronary Artery Disease, Autosomal Dominant, 1
NM_001350001.1:c.714G>A	NA	0.404	Coronary Artery Disease, Autosomal Dominant, 1
NM_001846.2:c.99+473=	NA	0.457	Coronary Artery Disease, Autosomal Dominant, 1
NM_001645.3:c.*459A>G	NA	0.160	Coronary Artery Disease, Autosomal Dominant, 1
NC_000001.11:g.109278889=	NA	0.228	Coronary Artery Disease, Autosomal Dominant, 1

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Remarks

Study with 914 individuals. 22 SNPs showed association with one or more cardio-metabolic traits in CAD patients (n=160). Following cardio-metabolic traits were studied: BMI, waist circumference, height, systolic blood pressure, diastolic blood pressure, fasting blood glucose, random blood glucose, HbA1c, total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride.

References

Osman et al. 2020

Related Subjects

Subject Id	Country	HPO Terms	Sex	Family History	Parental Consanguinity	Remarks
608320.G.2.1	United Arab Emirates	Myocardial infarction; Abnormal coronary artery morphology; Type II diabetes mellitus; Abnormal circulating lipid concentration; Hypertension	Unknown			160 subjects with CAD from a study consisting of 914 individuals. Two SNPs showed association with CAD.
608320.G.2.2	United Arab Emirates		Unknown			Group consisting of 332 control subjects.