Metabolic syndrome, formerly known as Syndrome X, is a condition characterized by clustering of certain factors that increase an individual's susceptibility to cardiovascular diseases, stroke, and diabetes. These factors include abdominal obesity, atherogenic dyslipidemia, hypertension, insulin resistance, and a prothrombotic and proinflammatory state. Diagnosis of the condition is fairly easy, and depends on a waist circumference >102 cm for men and 88 cm for women, triglycerides levels >150mg/dL, blood pressure >130/85 mm Hg, HDL cholesterol <40mg/dL in men and 50 mg/dL in women, and fasting glucose >100mg/dL.
Major risk factors for the condition include increasing age, racial predilection, with Asians and Hispanics showing a greater tendency to develop the disease, obesity, a history of diabetes or other diseases involving the endocrine system. Management primarily involves making lifestyle changes, such as loosing weight, exercising, stopping smoking, and reducing dietary fat intake. For many affected individuals, modifying their lifestyle itself is enough to control the condition. Some others, however, may also require antihypertensive and hypolipidemic medications in addition.