GPSM2 belongs to a group of proteins that modulate the activation of G proteins that transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 plays an essential role in maintaining cell polarity and spindle pole orientation. Dysfunction of GPSM2 is found to be associated with the phenotype of multiple micronuclei due to chromosomal mis-segregation and defect in cell division through mis-localization of mitotic spindle regulator protein NuMA.
